The Russian anxiolytic peptide used for stress, anxiety, and cognitive support — non-sedating, non-addictive, and active within 30 minutes of an intranasal dose.
Selank is a synthetic 7 amino acid peptide developed at the Russian Academy of Sciences in the 1990s as a non-sedating alternative to benzodiazepines. It’s derived from the immunomodulatory peptide tuftsin, which is why it also has mild immune-supportive effects.
In Russia it’s approved for generalized anxiety disorder. Unlike benzodiazepines, Selank does not produce sedation, cognitive dulling, tolerance, or dependence — and it can actually improve focus and working memory at typical doses.
Not FDA approved. Not WADA prohibited. Available as a research chemical; nasal spray formulations are common.
Modulates GABA-A receptor function and balances serotonergic tone — producing anxiolysis without direct receptor agonism. This is why it doesn’t cause sedation or dependence.
Elevates brain-derived neurotrophic factor, supporting neuroplasticity and cognitive resilience — similar mechanism to exercise and antidepressants.
Extends the activity of endogenous enkephalins by inhibiting their breakdown. Contributes to mood elevation and stress resilience.
Shares tuftsin-derived immune effects — mild antiviral and immune-supportive properties alongside the primary anxiolytic action.
| Benefit | Evidence |
|---|---|
| Anxiety reduction | Russian clinical trials for generalized anxiety disorder; comparable efficacy to medazepam without sedation |
| Focus & working memory | Improvements on attention and short-term memory tasks, particularly under stress |
| Stress resilience | Reduced cortisol response to acute stressors in animal studies |
| No tolerance / dependence | No withdrawal or rebound anxiety on discontinuation; suitable for intermittent use |
| Immune support | Mild antiviral and immune-modulating activity via tuftsin fragment |
Most human data comes from Russian publications; Western independent replication is limited.
Build your protocol, log every dose, monitor your body's response, and get reminders so you never miss a dose.
Start Tracking FreeSubQ is less common; most users prefer intranasal for convenience and rapid onset.
Can be used as-needed for acute stress/anxiety or as a 10–14 day cycle followed by a break. No tolerance has been reported. Worth knowing: PMID 25176261 shows Selank’s anxiolytic effect can persist for up to a week after the last dose, which has implications for how often you actually need to re-dose — a “brief course” may cover more days than it looks like on paper.
For DIY nasal spray preparation from lyophilized powder:
5 mg vial + 5 mL BAC water = 1 mg/mL. Typical nasal pump delivers ~100 µL (0.1 mL) per spray = 100 mcg per spray.
For a 250 mcg dose: 2–3 sprays (split between nostrils). For 500 mcg: 5 sprays.
Pre-filled with a typical Selank setup. Edit any field — the draw updates live.
Insulin syringe — 100 units = 1 mL
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Selank has one of the cleanest safety profiles of any anxiolytic — decades of clinical use in Russia with minimal adverse events.
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Build your protocol, log every dose, monitor your body's response, and get reminders so you never miss a dose.
Start Tracking FreeNo. Selank is a Russian-developed synthetic heptapeptide that has never been approved by the FDA, EMA, or any Western regulatory authority. It has Russian Ministry of Health approval for use in generalized anxiety disorder and neurasthenia. In the US it is sold only as a research chemical.
Russian clinical protocols use intranasal 0.15% spray, 250–500 mcg per dose, 1–3 times daily (total 500 mcg–2 mg/day) for 10–14 day courses. Western community usage closely mirrors this. Subcutaneous administration is less common and has no clinical-evidence base.
The vast majority of Selank use is intranasal. Many users reconstitute lyophilized vials with bacteriostatic water and load into a nasal spray bottle. A 5 mg vial + 2 mL BAC water yields 2.5 mg/mL — at 100 mcL per spray, that delivers 250 mcg per spray. Russian-clinic protocols use a 0.15% solution (1.5 mg/mL).
Onset of subjective anxiolytic effect is reported within 15–30 minutes intranasally. The Medvedev 2014 (PMID 25176261) Russian RCT reported anxiolytic effects "lasting for a week after the last dose" of a 14-day course — but this single small Russian trial is striking, unreplicated, and in tension with Selank’s ~minute-scale plasma half-life. Treat that "one-week persistence" as a single finding, not established pharmacology.
Both are short Russian Pro-Gly-Pro–stabilized peptides with overlapping cognitive/anxiolytic profiles. Community users often stack them — Selank for the anxiolytic/calming angle and Semax for the stimulant/focus angle. There are no controlled trials of the combination. Doses, frequencies, and cycles are all community convention.
Not specifically named on the WADA Prohibited List as of 2025–2026. WADA reserves discretion to sweep peptides under broad class language (S0 — Non-Approved Substances). Competitive athletes should verify the current-year list before use.
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StackTrax guides cover peptides and compounds that are not FDA-approved for the uses discussed. The dosing, reconstitution, and safety information is compiled from published research and community protocols for educational purposes only.
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