The cleanest GHRP ever made — triggers a natural GH pulse without the cortisol, prolactin, or hunger spikes that plague older growth-hormone peptides.
Ipamorelin is a synthetic pentapeptide that selectively activates the ghrelin (growth hormone secretagogue) receptor to trigger natural GH release. It was developed by Novo Nordisk in the 1990s specifically to isolate the GH-releasing effect from the unwanted hormonal side effects of older GHRPs.
Unlike GHRP-2 or GHRP-6, ipamorelin does not meaningfully raise cortisol, prolactin, ACTH, or aldosterone — and it does not cause the strong hunger spikes that earlier GHRPs are known for. This selectivity is its main advantage.
Not FDA approved. WADA prohibited (S2 — Peptide Hormones). Available as a research chemical.
Binds the ghrelin receptor on the pituitary and triggers a natural GH pulse. Unlike older GHRPs, it does not activate the HPA axis — so cortisol and prolactin stay near baseline.
When paired with a GHRH analog like CJC-1295 or sermorelin, ipamorelin amplifies the pulse several-fold — which is why the CJC+Ipa stack is so popular. Alone, the pulse is smaller but still meaningful.
Stimulates your own GH production rather than replacing it, so natural feedback loops stay intact — unlike exogenous HGH.
| Benefit | Evidence |
|---|---|
| Sleep quality | Pre-bed pulse improves slow-wave sleep; most reliable benefit |
| Recovery | Faster exercise and soft-tissue recovery via downstream IGF-1 |
| Body composition | Modest lean mass gains and fat reduction over 8–12 weeks |
| Low side effect burden | Raychaudhuri et al.: no meaningful change in cortisol, prolactin, or aldosterone at clinical doses |
| Skin & hair | Improved collagen synthesis, hair quality — slower than CJC+Ipa due to smaller IGF-1 effect |
Build your protocol, log every dose, monitor your body's response, and get reminders so you never miss a dose.
Start Tracking FreeCombined with CJC-1295 (100 mcg) or sermorelin (200–500 mcg) pre-bed to amplify the pulse. This is the standard modern growth-hormone peptide protocol. See the CJC-1295 + Ipamorelin guide for full details.
100–300 mcg is the effective range. More than 300 mcg produces diminishing returns; the pituitary’s pulse ceiling is reached quickly. For more total GH exposure, add pulses (up to 3 daily), not bigger per-dose amounts.
5 mg vial + 2.5 mL BAC water = 2 mg/mL = 2000 mcg/mL
| Dose | Volume | Syringe Units |
|---|---|---|
| 100 mcg | 0.05 mL | 5 units |
| 200 mcg | 0.10 mL | 10 units |
| 300 mcg | 0.15 mL | 15 units |
5 mg vial at 200 mcg 2×/day = ~12 days
Use our free peptide calculator to figure out your reconstitution volume, draw amount, and syringe units.
Open Peptide CalculatorDosing cheat sheet, reconstitution reference, and cycle planning — delivered to your inbox.
Ipamorelin has one of the cleanest side-effect profiles of any GHRP — that’s the whole point.
Looking for Ipamorelin? We recommend NextGen Peptides — third-party tested, fast shipping, and trusted by the StackTrax community.
10% off with code
Exclusive StackTrax discount
Build your protocol, log every dose, monitor your body's response, and get reminders so you never miss a dose.
Start Tracking FreeDisclaimer: This guide is for educational and informational purposes only and is not intended as medical advice, diagnosis, or treatment. The compounds discussed are not FDA approved for human use. Always consult a qualified healthcare provider before starting any new supplement or peptide protocol. StackTrax does not sell peptides or supplements directly — purchase links go to third-party vendors. StackTrax is not responsible for the products, quality, or business practices of any third-party vendor. This page contains affiliate links — StackTrax may earn a commission on purchases at no extra cost to you.
© 2026 StackTrax, LLC. All rights reserved.
StackTrax guides cover peptides and compounds that are not FDA-approved for the uses discussed. The dosing, reconstitution, and safety information is compiled from published research and community protocols for educational purposes only.
Before using any compound mentioned here, consult a qualified healthcare provider. StackTrax does not sell, prescribe, or recommend these substances for personal use.
These pages also contain affiliate links. We may earn a commission on purchases at no extra cost to you — this never changes our editorial recommendations.