The gold-standard GH peptide stack — a GHRH + GHRP combo that triggers natural pulsatile growth hormone release for better recovery, sleep, and body composition.
CJC-1295 (no DAC), also known as Mod GRF 1-29, is a Growth Hormone Releasing Hormone (GHRH) analog. It tells your pituitary to make more GH. “No DAC” means no Drug Affinity Complex, which gives it a short half-life (~30 minutes) that mimics natural GH pulses.
Ipamorelin is a Growth Hormone Releasing Peptide (GHRP) that acts on the ghrelin receptor to amplify the GH pulse — but unlike older GHRPs, it does NOT spike cortisol, prolactin, or hunger significantly.
Used together, they produce a synergistic GH pulse — larger than either alone and closer to the body’s natural pattern. This is why they are the most common peptide stack in anti-aging, recovery, and body composition protocols.
Not FDA approved. WADA prohibited (S2 — Peptide Hormones). Available as research chemicals.
Binds the GHRH receptor on the anterior pituitary, triggering natural GH release. Because there’s no DAC, the signal fades within 30 minutes — matching endogenous GH pulse biology.
Selectively activates the ghrelin (GHS) receptor to amplify the GH pulse from CJC-1295. Ipamorelin is unique among GHRPs for NOT stimulating cortisol, prolactin, or significant hunger.
CJC + Ipa together produce a GH pulse that is larger than the sum of either alone — a true synergy. The pulse triggers IGF-1 production in the liver, which drives most of the downstream benefits.
Because this stack stimulates your own GH production (not replaces it), the hypothalamic feedback loop stays intact. Less risk of shutting down natural production compared to direct HGH.
CJC-1295 and Ipamorelin have each been studied in clinical trials. The combined stack is well-established in anti-aging and bodybuilding communities.
| Benefit | Evidence |
|---|---|
| Deeper sleep | Pre-bed pulse restores slow-wave sleep; most consistent user-reported benefit |
| Recovery | Faster soft-tissue and muscle recovery between training sessions |
| Body composition | Lean mass gains and fat loss, particularly visceral fat; IGF-1-mediated |
| Skin quality | Improved collagen, reduced fine lines, thicker healthier skin |
| Energy & well-being | Sustained energy, improved mood and motivation over 8–12 weeks |
| Bone density | Long-term GH/IGF-1 elevation supports bone mineral density |
Build your protocol, log every dose, monitor your body's response, and get reminders so you never miss a dose.
Start Tracking Free100 mcg is the commonly cited starting/working dose for each peptide, widely described in community protocols as a practical saturation point beyond which returns diminish. A specific 100 mcg pharmacodynamic ceiling is not confirmed in the peer-reviewed abstracts available for CJC-1295/Ipamorelin — treat it as practitioner convention rather than an established pharmacological ceiling. If you want more total GH exposure, add more pulses per day (up to 3), not higher per-dose amounts.
Both peptides are commonly sold as 5 mg lyophilized powder. You can reconstitute them separately or combine into a blend vial.
5 mg vial + 2.5 mL BAC water = 2 mg/mL = 2000 mcg/mL
| Dose (each peptide) | Volume | Syringe Units |
|---|---|---|
| 100 mcg | 0.05 mL | 5 units |
| 200 mcg | 0.10 mL | 10 units |
| 300 mcg | 0.15 mL | 15 units |
One 5 mg vial at 100 mcg/day = 50 days. With CJC + Ipa stacked, one full blend vial = ~25 days of single daily pulse.
All compounds share one vial. Edit any amount or change the Ipamorelin dose — the other doses scale by ratio.
Insulin syringe — 100 units = 1 mL
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GH and IGF-1 elevation may promote growth of existing malignancies. Do not use if you have any cancer history.
How fast do I see results?
Sleep improvements within the first week. Recovery and skin quality by 4 weeks. Body composition changes by 8–12 weeks.
CJC-1295 with DAC vs. no DAC?
“With DAC” is commonly described as having a multi-day half-life that creates a GH bleed rather than a pulse, and practitioners argue this can desensitize receptors and blunt natural pulses. These PK and receptor-desensitization claims are widely held clinical opinion based on CJC-1295’s albumin-binding design, but not tightly established by peer-reviewed PK comparisons in the abstracts reviewed for this guide. Most experienced users still prefer “no DAC” for pulsatile, physiological dosing.
Do I need to cycle?
Long-term continuous use is generally well tolerated, but 8–12 week on / 2–4 week off cycles help maintain receptor sensitivity and let IGF-1 return to baseline.
Why not just use HGH?
HGH is direct replacement and shuts down your own pituitary output. CJC+Ipa preserves natural pulsatility and feedback, and is significantly cheaper.
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Build your protocol, log every dose, monitor your body's response, and get reminders so you never miss a dose.
Start Tracking FreeCJC-1295 (no DAC), also known as Mod GRF 1-29, is a GHRH analog that tells the pituitary to make more growth hormone. Ipamorelin is a GHRP that acts on the ghrelin receptor to amplify the GH pulse without spiking cortisol, prolactin, or hunger the way older GHRPs do. Used together they produce a synergistic GH pulse that is larger than either alone and closer to natural pulsatile biology. Neither is FDA approved and both are WADA prohibited under S2 (Peptide Hormones).
The standard CJC + Ipa stack uses CJC-1295 no DAC (Mod GRF 1-29), which has roughly a 30-minute half-life that mimics natural GH pulses. CJC with DAC is commonly described as having a multi-day half-life that creates a GH bleed rather than a pulse, and practitioners argue this can desensitize receptors and blunt natural pulses. Those PK and desensitization claims are widely held clinical opinion based on the albumin-binding design but are not tightly established by peer-reviewed PK comparisons. Most experienced users still prefer no DAC for pulsatile, physiological dosing.
Standard protocol is 100 mcg of each peptide mixed in the same syringe, injected SubQ 1 to 3 times per day, on a 5 days on / 2 days off pattern or in 8 to 12 week cycles. The pre-bed dose is the most important because it enhances slow-wave sleep and the overnight IGF-1 pulse. Inject at least 2 hours after eating since carbs and fats blunt the GH pulse. An optional second dose 30 to 45 minutes pre-workout supports recovery.
100 mcg is the commonly cited starting and working dose for each peptide, widely described in community protocols as a practical saturation point beyond which returns diminish. A specific 100 mcg pharmacodynamic ceiling is not confirmed in the peer-reviewed abstracts available for CJC-1295 or Ipamorelin, so treat it as practitioner convention rather than an established pharmacological ceiling. If you want more total GH exposure, add more pulses per day (up to 3) rather than higher per-dose amounts.
Sleep improvements show up within the first week and are the most consistent user-reported benefit. Recovery and skin quality typically improve by 4 weeks. Body composition changes (lean mass gains and visceral fat loss, mediated by IGF-1) and bone density support show up over 8 to 12 weeks.
Common effects include facial flushing lasting about 10 minutes after injection (a known effect of GH secretagogue combinations), head rush or lightheadedness, tingling in extremities, vivid dreams (especially with the pre-bed dose), and mild water retention. Less common are carpal tunnel-like numbness, elevated fasting glucose, and injection site reactions. Contraindicated with active cancer or history of malignancy, active retinopathy, pregnancy or breastfeeding, and under age 25 (growth plates). Type 2 diabetes or insulin resistance warrants glucose monitoring since GH is counter-regulatory.
HGH is direct hormone replacement and shuts down the pituitary's own output. CJC + Ipa stimulates your own GH production, so the hypothalamic feedback loop stays intact and there is less risk of suppressing natural production. It is also significantly cheaper than HGH. Long-term continuous use is generally well tolerated, but 8 to 12 week on / 2 to 4 week off cycles help maintain receptor sensitivity and let IGF-1 return to baseline.
Disclaimer: This guide is for educational and informational purposes only and is not intended as medical advice, diagnosis, or treatment. The compounds discussed are not FDA approved for human use. Always consult a qualified healthcare provider before starting any new supplement or peptide protocol. StackTrax does not sell peptides or supplements directly — purchase links go to third-party vendors. StackTrax is not responsible for the products, quality, or business practices of any third-party vendor. This page contains affiliate links — StackTrax may earn a commission on purchases at no extra cost to you.
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StackTrax guides cover peptides and compounds that are not FDA-approved for the uses discussed. The dosing, reconstitution, and safety information is compiled from published research and community protocols for educational purposes only.
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