The premium GHRH + GHRP stack — tesamorelin’s visceral-fat-targeting firepower plus ipamorelin’s clean GH pulse. The most potent pulsatile GH protocol short of actual HGH.
A combined GHRH + GHRP protocol that pairs tesamorelin (the FDA-approved GHRH analog originally used for HIV lipodystrophy visceral fat) with ipamorelin (the selective GHRP with no cortisol or prolactin side effects).
It’s essentially a "premium CJC-1295 + Ipamorelin" — the tesamorelin component produces a stronger, more reliable GH pulse than CJC-1295 no-DAC, with specific preferential effects on visceral adipose tissue. The trade-off is higher cost and shorter reconstituted shelf life.
Tesamorelin is FDA approved (Egrifta) for HIV lipodystrophy; ipamorelin is not FDA approved. Both WADA prohibited (S2). The stack is used off-label; available as separate peptides or pre-mixed blend.
Potent GHRH analog with higher pituitary binding affinity and longer half-life than CJC-1295 no-DAC. Drives a larger, more reliable GH pulse. Strong preferential effect on visceral (deep belly) fat reduction via IGF-1-mediated lipolysis.
Selectively activates GHS-R without the cortisol/prolactin/aldosterone side effects of older GHRPs. Amplifies the GH pulse from tesamorelin without adding side-effect baggage.
Like CJC+Ipa, the combination produces a larger GH pulse than either component alone. With tesamorelin as the base, the pulse is noticeably stronger — reflected in both IGF-1 elevation and clinical visceral fat outcomes.
| Benefit | Evidence |
|---|---|
| Visceral fat loss | Tesamorelin’s Phase 3: 15–18% VAT reduction at 26 weeks; stack amplifies via ipamorelin pulse |
| Sleep quality | Pre-bed pulse restores slow-wave sleep reliably |
| Body composition | Lean mass preservation during fat loss; stronger than CJC+Ipa per dose |
| Liver fat / NAFLD | Tesamorelin reduces hepatic fat ~40% in NAFLD trials |
| Recovery | Faster soft-tissue recovery between training sessions |
| Skin quality | Increased collagen synthesis; thicker, healthier skin over 8–12 weeks |
Build your protocol, log every dose, monitor your body's response, and get reminders so you never miss a dose.
Start Tracking FreeBegin at 1 mg tesamorelin + 100 mcg ipamorelin for 2–4 weeks to assess water retention, glucose response, and overall tolerance. Titrate to 2 mg tesa if tolerated.
IGF-1 (expect ~50% rise at full dose), fasting glucose, HbA1c, lipids. Measure at baseline and every 3 months. DEXA or waist circumference at baseline and 12 weeks to track visceral fat change.
Commonly supplied as a pre-mixed blend (e.g. 5 mg tesamorelin + 5 mg ipamorelin in one vial). Can also be reconstituted separately.
5 mg tesa + 5 mg ipa blend + 2 mL BAC water = 5 mg/mL total (2.5 mg each peptide per mL)
| Target (Tesa + Ipa) | Volume | Syringe Units |
|---|---|---|
| 1 mg + 1 mg | 0.40 mL | 40 units |
| 2 mg + 2 mg | 0.80 mL | 80 units |
If you want tesamorelin at 2 mg but only 100–200 mcg of ipamorelin, reconstitute them separately instead. Check your specific vial’s ratios.
Use our free peptide calculator to figure out your reconstitution volume, draw amount, and syringe units.
Open Peptide CalculatorDosing cheat sheet, reconstitution reference, and cycle planning — delivered to your inbox.
Elevated GH/IGF-1 may promote existing tumor growth. Avoid with any malignancy history.
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Build your protocol, log every dose, monitor your body's response, and get reminders so you never miss a dose.
Start Tracking FreeDisclaimer: This guide is for educational and informational purposes only and is not intended as medical advice, diagnosis, or treatment. The compounds discussed are not FDA approved for human use. Always consult a qualified healthcare provider before starting any new supplement or peptide protocol. StackTrax does not sell peptides or supplements directly — purchase links go to third-party vendors. StackTrax is not responsible for the products, quality, or business practices of any third-party vendor. This page contains affiliate links — StackTrax may earn a commission on purchases at no extra cost to you.
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StackTrax guides cover peptides and compounds that are not FDA-approved for the uses discussed. The dosing, reconstitution, and safety information is compiled from published research and community protocols for educational purposes only.
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