The melanocortin peptide that works on the brain rather than the bloodstream — FDA approved as Vyleesi for female sexual arousal, and widely used off-label for male libido.
PT-141, also known as bremelanotide, is a synthetic analog of alpha-MSH (α-melanocyte-stimulating hormone) and a selective agonist at the melanocortin-4 receptor (MC4R). Unlike erectile dysfunction drugs that act on blood flow, PT-141 works in the central nervous system — it increases sexual desire and arousal.
It is FDA approved as Vyleesi for hypoactive sexual desire disorder (HSDD) in premenopausal women. Off-label use for male libido and erectile dysfunction is widespread and generally well tolerated.
FDA approved (Vyleesi) for premenopausal HSDD. Not WADA prohibited. Available as research chemical for off-label use.
Activates MC4R in the hypothalamus, triggering downstream dopamine release in sexually-relevant brain circuits — drives desire and arousal at a central level, not peripheral.
Because PT-141 acts on desire rather than blood flow, it can work for people who don’t respond to Viagra/Cialis — or who have psychogenic issues that require a libido boost rather than vascular support.
Onset typically 30–60 minutes post-injection, duration 4–6 hours. Effects can persist subtly for 12+ hours in some users.
| Benefit | Evidence |
|---|---|
| Female libido (HSDD) | RECONNECT trials: statistically significant improvement in desire and arousal over placebo |
| Male erectile function | Phase 2 trials (Diamond et al.): 33% of non-responders to PDE-5s achieved satisfactory erections |
| Complement to PDE-5s | Combines effectively with sildenafil/tadalafil when needed (clinician supervision recommended) |
| Postmenopausal benefits | Anecdotal and off-label data suggest improvements beyond the FDA-approved premenopausal population |
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Start Tracking FreeImportant: FDA approval and Phase 3 efficacy evidence for bremelanotide are limited to premenopausal women with HSDD (PMIDs 31893927, 31599847, 33455598, 35147466). Male dosing is off-label and lacks the same evidence base — treat the 1–2 mg male range as community convention, not trial-validated.
10 mg vial + 2 mL BAC water = 5 mg/mL
| Dose | Volume | Syringe Units |
|---|---|---|
| 0.5 mg | 0.10 mL | 10 units |
| 1 mg | 0.20 mL | 20 units |
| 1.75 mg | 0.35 mL | 35 units |
| 2 mg | 0.40 mL | 40 units |
10 mg vial at 1.75 mg/use = ~5 doses per vial
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Phase 3 meta-analysis (PMID 33678061) showed bremelanotide-treated subjects had substantially higher adverse-event-driven discontinuation than placebo (OR ~12, NNH ~6) — roughly 1 in 6 users may stop due to side effects. Long-term open-label data (PMID 31599847) echoes the tolerability burden. This is why the starter-dose approach matters: confirm you can tolerate a smaller dose before escalating.
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Start Tracking FreeDisclaimer: This guide is for educational and informational purposes only and is not intended as medical advice, diagnosis, or treatment. The compounds discussed are not FDA approved for human use. Always consult a qualified healthcare provider before starting any new supplement or peptide protocol. StackTrax does not sell peptides or supplements directly — purchase links go to third-party vendors. StackTrax is not responsible for the products, quality, or business practices of any third-party vendor. This page contains affiliate links — StackTrax may earn a commission on purchases at no extra cost to you.
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