The lipotropic "fat-melting" injection used in medical weight-loss clinics for decades — a blend of methionine, inositol, choline, and B12 that supports fat metabolism.
Lipo-C is a lipotropic injection blend of essential nutrients that support liver fat metabolism. The classic formulation is known as MIC: Methionine, Inositol, Choline. Most modern versions (including Lipo-C+) add vitamin B12 (cyanocobalamin or methylcobalamin) plus additional B vitamins and amino acids like L-carnitine.
It’s been used in weight-loss clinics since the 1970s. Unlike GLP-1 drugs, it doesn’t suppress appetite or directly drive weight loss — it supports the body’s ability to process and mobilize fat, especially in the liver. Best viewed as metabolic support during a caloric deficit.
Not FDA approved as a weight-loss drug (individual ingredients are approved). Not WADA prohibited. Available from compounding pharmacies and research suppliers.
Essential amino acid and methyl donor. Required for the liver to produce lecithin, which emulsifies and mobilizes fat for transport and burning.
A sugar alcohol that supports insulin signaling and serotonin synthesis. Plays a role in hepatic lipid handling and can improve fasting insulin.
Critical for VLDL synthesis and fat export from the liver. Choline deficiency causes hepatic steatosis (fatty liver). Lipo-C ensures adequate supply for fat export.
Cofactors for cellular energy metabolism. B12 specifically supports red blood cell formation, nerve health, and methylation reactions. Usually added in high dose.
Often added to premium Lipo-C formulations. Shuttles long-chain fatty acids into mitochondria for beta-oxidation (fat burning).
Lipo-C as a proprietary blend has limited RCT data, but its individual components are well-studied.
| Benefit | Evidence |
|---|---|
| Fat mobilization | Mechanistically supports hepatic fat export; works best during caloric deficit |
| Energy | B12 deficiency is common; correction restores energy levels |
| Liver support | Choline addresses NAFLD-related fat buildup |
| Mood / cognition | B vitamin support improves methylation and mood in deficient patients |
| Adjunct to GLP-1s | Many providers add Lipo-C to semaglutide / tirzepatide protocols for metabolic support during rapid weight loss |
Expect modest, gradual support — not dramatic weight loss on its own.
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Start Tracking FreeSome weight-loss clinics dose 1 mL 2–3× per week during active weight loss. Not necessarily more effective than weekly; individual response varies.
Lipo-C comes as a pre-mixed sterile injectable liquid in multi-dose vials. No reconstitution needed. Typical vial is 10 or 30 mL.
Standard strength is ready-to-inject. 1 mL = 1 full dose. Most insulin syringes (1 mL cap) work; larger 3 mL syringes are more comfortable for IM.
Pre-filled with a typical Lipo-C setup. Edit any field — the draw updates live.
Insulin syringe — 100 units = 1 mL
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Start Tracking FreeNo. Lipo-C / MIC (Methionine + Inositol + Choline, often combined with B12, B6, and L-carnitine) is NOT FDA approved as a weight-loss drug — no NDA exists for the blend. The compounded injectable is produced by 503A pharmacies. Some individual components are FDA approved for unrelated indications: cyanocobalamin (B12) injection for B12 deficiency, levocarnitine (Carnitor) for primary carnitine deficiency — but those approvals do not transfer to the lipotropic blend.
The classic MIC base is Methionine (an essential amino acid), Inositol (a sugar alcohol involved in lipid signaling), and Choline (a precursor to phosphatidylcholine and acetylcholine). Most commercial Lipo-C blends add cyanocobalamin (vitamin B12), pyridoxine (B6), and sometimes L-carnitine. Exact mg/mL per ingredient varies by compounding pharmacy — Lipo-C+, Lipo-NAD, Lipo-Mino, and similar variants have different formulations.
Community / med-spa convention: 1 mL of the compounded blend, injected 1–3 times per week, intramuscularly (glute or deltoid) or subcutaneously. No Phase 2/3 RCTs have established an optimal dose, frequency, or duration for the MIC/Lipo-C blend — these protocols are practitioner convention, not trial-derived.
It ships ready-to-inject (no reconstitution needed) as a clear-to-slightly-yellow solution. Most clinics inject intramuscularly into the gluteal muscle or deltoid; subcutaneous abdominal injection is also done. Aspirate to confirm not in a vessel before injecting if using IM. Rotate sites to avoid local irritation.
There is no peer-reviewed RCT evidence that the MIC/Lipo-C blend produces clinically meaningful weight loss in humans. Individual components have mechanistic rationale (choline + methionine support hepatic lipid metabolism; B12 corrects deficiency in some patients) but the blend has not been validated as an independent weight-loss intervention. When used adjunct to GLP-1s (semaglutide, tirzepatide), the weight loss is from the GLP-1 — there is no RCT support for added benefit from Lipo-C in that combination.
Per clinic-practice safety records, Lipo-C is generally well tolerated. Local injection-site reactions (soreness, bruising) are the most common. Anaphylaxis is rare but possible — particularly to the B12 or preservative components. Patients with severe hepatic impairment, pregnancy, or active malignancy should consult a clinician before use. There is no large post-marketing safety database because the blend is not a registered drug.
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