The fat-loss fragment of growth hormone — provides the lipolytic effects of HGH without the blood sugar and growth-related side effects.
AOD-9604 is a 16 amino acid fragment of human growth hormone corresponding to residues 176–191 — the portion of the HGH molecule responsible for fat metabolism. It was engineered by Monash University researchers specifically to separate the lipolytic (fat-burning) effects of HGH from the anabolic and metabolic effects.
Because AOD-9604 does not raise IGF-1, blood sugar, or interact with GH receptors the way intact HGH does, it has a cleaner side effect profile — but it is also less potent than full HGH or modern GLP-1 drugs for weight loss.
Not FDA approved. GRAS status in Australia. Not WADA prohibited. Available as a research chemical.
Stimulates beta-3 adrenergic receptors on fat cells, triggering breakdown of stored triglycerides. This is the same pathway as exercise-induced fat mobilization.
Blocks the conversion of dietary carbohydrates into new fat storage. Combined with lipolysis, this shifts the body toward using fat as fuel.
Because AOD-9604 doesn’t activate the GH receptor itself, it doesn’t raise IGF-1, increase insulin resistance, or affect growth in tissues. This is both its safety advantage and its efficacy limit.
Phase 2 trials for obesity in the early 2000s showed modest but consistent fat loss. Development was eventually halted for commercial reasons.
| Benefit | Evidence |
|---|---|
| Fat loss | Phase 2b: ~2.6 kg fat loss over 12 weeks vs. placebo; modest but real |
| Visceral fat targeting | Preferential reduction of visceral vs subcutaneous fat |
| Cartilage repair | Preclinical data suggests chondrocyte stimulation; explored for joint/cartilage applications |
| Lean mass neutral | No muscle loss during fat loss; unlike aggressive caloric restriction |
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Start Tracking FreeAOD-9604 is commonly stacked with CJC-1295/Ipamorelin for complementary fat loss and with GLP-1s (semaglutide/tirzepatide) for appetite + lipolysis — though note the “no IGF-1 involvement” framing is a simplification: PMID 41490200 associates AOD-9604 with IGF-1 signaling pathways, so it’s not cleanly free of that axis. A reported MOTS-C (AMPK) synergy is community speculation with no mechanistic evidence in peer-reviewed abstracts.
5 mg vial + 2 mL BAC water = 2500 mcg/mL
| Dose | Volume | Syringe Units |
|---|---|---|
| 250 mcg | 0.10 mL | 10 units |
| 500 mcg | 0.20 mL | 20 units |
5 mg vial at 300 mcg/day = ~16 days
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AOD-9604 is remarkably well tolerated — most clinical adverse events were mild and comparable to placebo.
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Start Tracking FreeDisclaimer: This guide is for educational and informational purposes only and is not intended as medical advice, diagnosis, or treatment. The compounds discussed are not FDA approved for human use. Always consult a qualified healthcare provider before starting any new supplement or peptide protocol. StackTrax does not sell peptides or supplements directly — purchase links go to third-party vendors. StackTrax is not responsible for the products, quality, or business practices of any third-party vendor. This page contains affiliate links — StackTrax may earn a commission on purchases at no extra cost to you.
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