An oral small molecule that blocks NNMT — preserving cellular NAD+ and SAM levels, with early data for fat loss, muscle regeneration, and metabolic health.
5-Amino-1-methylquinolinium, or 5-Amino-1MQ, is an oral small molecule inhibitor of NNMT (nicotinamide N-methyltransferase). NNMT methylates nicotinamide (vitamin B3) into a waste product, consuming both NAD+ precursors and SAM (methyl donors). Blocking NNMT preserves NAD+, SAM, and favorably shifts cellular metabolism.
Unlike most peptides on this site, 5-Amino-1MQ is a small molecule taken orally — no injections. It was developed academically and has not yet completed Phase 3 human trials, but the preclinical data are compelling for muscle regeneration, fat loss, and metabolic health.
Not FDA approved. Not WADA prohibited as of current list. Available as research chemical.
NNMT uses SAM (methyl donor) to convert nicotinamide into 1-MNA, which is excreted. Inhibiting NNMT preserves both NAD+ precursor pool and the SAM methyl-donor pool — critical for DNA methylation and hundreds of methylation reactions.
More nicotinamide available for the NAD+ salvage pathway means higher cellular NAD+ — a complementary mechanism to oral NMN or injectable NAD+.
NNMT is elevated in aging muscle and obesity-expanded adipose tissue. Inhibiting it in muscle enhances stem cell function (satellite cells) and in fat tissue increases metabolic rate and lipolysis.
| Benefit | Evidence |
|---|---|
| Fat loss | Mouse studies: ~7% body fat loss without caloric restriction |
| Muscle regeneration | Restored satellite cell function in aged mice; improved recovery from injury |
| Metabolic rate | Increased energy expenditure via enhanced fat oxidation |
| Insulin sensitivity | Preclinical improvements in glucose handling |
| NAD+ levels | Elevates cellular NAD+ via preserved nicotinamide |
Note: Human clinical data are limited. Most benefits are from preclinical models.
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Start Tracking FreeStart at 50 mg/day for the first 1–2 weeks to assess tolerance before titrating up.
5-Amino-1MQ is taken orally as capsules — no reconstitution needed.
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