The HPG-axis master regulator — acts upstream of LH and FSH to restore natural reproductive-hormone function, with emerging clinical data in fertility and libido research.
Kisspeptin-10 (KP-10) is the C-terminal decapeptide of the KISS1 gene product — a neuropeptide that acts as the most upstream regulator of the hypothalamic-pituitary-gonadal (HPG) axis. Kisspeptin-producing neurons release it onto GnRH neurons; GnRH then triggers pituitary LH and FSH release, which drives testicular or ovarian function.
Pioneering clinical work at Imperial College London (Dhillo and colleagues) has demonstrated meaningful effects of kisspeptin on reproductive hormone release, sexual brain activity, and bonding — all without the HPG-suppression concern of direct TRT.
Not FDA approved. Not WADA prohibited. Actively studied in humans; research chemical for off-label use.
Binds KISS1R (also called GPR54) on GnRH neurons in the hypothalamus. GnRH is the master signal to the pituitary to release LH and FSH.
Because kisspeptin acts above GnRH, it triggers the entire cascade: GnRH → LH/FSH → testicular testosterone and spermatogenesis (or ovarian estradiol + follicular development). This is fundamentally different from TRT (which bypasses and suppresses the axis) or HCG (which stimulates testes directly).
Kisspeptin receptors are expressed in limbic regions. Imperial studies show intranasal kisspeptin enhances brain activity in sexual / bonding circuits in men, suggesting central effects beyond pure HPG activation.
| Benefit | Evidence |
|---|---|
| LH / testosterone pulse | Reliable triggering of LH surge + downstream testosterone in men with functional HPG |
| Fertility (IVF) | Kisspeptin-triggered IVF cycles showed lower ovarian hyperstimulation syndrome risk vs hCG trigger |
| Libido / arousal (men) | Imperial College fMRI studies: increased sexual brain circuit activity + subjective libido with intranasal or IV kisspeptin |
| Hypogonadotropic hypogonadism | Research suggests potential to restart HPG axis in functional hypothalamic cases |
| HPG axis recovery | Community interest as a PCT tool after anabolic cycles; clinical data limited |
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Start Tracking FreeClinical trials have used a wide dose range (weight-based, nanograms per kg). Community doses run substantially higher than trial doses because research-chem peptide grade varies.
Kisspeptin stimulates your own testicular testosterone via the full HPG cascade. For men with a functional axis (primary or functional hypothalamic hypogonadism), this is ideal. For men with primary testicular failure, it won’t work — the testes themselves can’t respond.
5 mg vial + 2 mL BAC water = 2500 mcg/mL
| Dose | Volume | Syringe Units |
|---|---|---|
| 100 mcg | 0.04 mL | 4 units |
| 200 mcg | 0.08 mL | 8 units |
| 300 mcg | 0.12 mL | 12 units |
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Kisspeptin-10 is a research peptide not approved by the FDA for human use. It is sold only as a research chemical, and StackTrax does not endorse or facilitate personal use.
Quality varies enormously among research-chemical suppliers. At minimum, look for:
StackTrax’s preferred partner NextGen Peptides does not currently carry Kisspeptin-10in their catalog, which is why you don’t see a direct purchase link here. Other major research-chemical suppliers carry it; we don’t specifically recommend one for this compound.
Build your protocol, log every dose, monitor your body's response, and get reminders so you never miss a dose.
Start Tracking FreeDisclaimer: This guide is for educational and informational purposes only and is not intended as medical advice, diagnosis, or treatment. The compounds discussed are not FDA approved for human use. Always consult a qualified healthcare provider before starting any new supplement or peptide protocol. StackTrax does not sell peptides or supplements directly — purchase links go to third-party vendors. StackTrax is not responsible for the products, quality, or business practices of any third-party vendor. This page contains affiliate links — StackTrax may earn a commission on purchases at no extra cost to you.
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StackTrax guides cover peptides and compounds that are not FDA-approved for the uses discussed. The dosing, reconstitution, and safety information is compiled from published research and community protocols for educational purposes only.
Before using any compound mentioned here, consult a qualified healthcare provider. StackTrax does not sell, prescribe, or recommend these substances for personal use.
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