The nine-amino-acid peptide originally isolated from sleeping rabbits — studied for decades as a deep-sleep enhancer, though Western research has never fully embraced the claims.
DSIP (Delta Sleep-Inducing Peptide) is a 9 amino acid peptide first isolated from the cerebral venous blood of sleeping rabbits in 1974 by Monnier and colleagues. The name reflects its initial identification as something that induced delta-wave (slow-wave) sleep when injected into other rabbits.
Decades of subsequent research have been mixed. The peptide exists endogenously in humans, has measurable effects on stress and pain pathways, and has been studied in clinical trials for depression, chronic pain, and withdrawal syndromes. The consistent deep-sleep effect seen in early rabbit work has been harder to replicate in humans.
Not FDA approved. Not WADA prohibited. Research chemical with limited modern human trial data.
Crosses the blood-brain barrier and modulates several neurotransmitter systems including opioid, GABA, and serotonin pathways. Mechanism is multi-target rather than a single clean receptor interaction — which is partly why effects are inconsistent.
Reduces cortisol and ACTH release in response to stress in animal models. Also modulates pain signaling in opioid-adjacent ways, which is why it’s been studied for chronic pain and opioid withdrawal.
Plasma half-life is about 7 minutes — paradoxically short for a compound whose effects are reported to last overnight. One hypothesis: transient receptor activation triggers downstream cascades that outlast the peptide itself.
| Benefit | Evidence |
|---|---|
| Sleep quality | Mixed; Russian and Eastern European studies report improved deep-sleep percentage; Western replications inconsistent |
| Stress / anxiety | Consistent anti-stress effect in animal models; human data weaker |
| Chronic pain | Small studies show reductions in chronic pain scores |
| Withdrawal syndromes | Studied as an adjunct for opioid and alcohol withdrawal; Russian clinical use |
| Depression | Inconsistent; mixed Eastern European results |
Anecdotal reports in the peptide community commonly describe vivid dreams and improved subjective sleep quality but not the dramatic sleep induction the name implies.
Build your protocol, log every dose, monitor your body's response, and get reminders so you never miss a dose.
Start Tracking FreeThe only published human dose in the available literature (PMID 6895513) used intravenous infusion at ~25 nmol/kg (roughly 1,500 mcg total for a 70 kg adult). SubQ and intranasal routes at 100–300 mcg are extrapolated from peptide-community practice — not established in controlled human trials. U-shaped dose-response has also been described (PMID 6145137), meaning higher doses can produce less effect, not more.
Most users treat DSIP as a PRN or short-cycle tool rather than continuous therapy. 10–14 day cycles followed by 2–4 week breaks. Long-term tolerance data in humans are limited — the absence of reported tolerance should not be interpreted as confirmed safety in extended use.
5 mg vial + 2 mL BAC water = 2500 mcg/mL
| Dose | Volume | Syringe Units |
|---|---|---|
| 100 mcg | 0.04 mL | 4 units |
| 200 mcg | 0.08 mL | 8 units |
| 300 mcg | 0.12 mL | 12 units |
Use our free peptide calculator to figure out your reconstitution volume, draw amount, and syringe units.
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DSIP has an excellent reported safety profile. Decades of use in Eastern European clinical protocols have produced minimal adverse event reports.
DSIP (Delta Sleep-Inducing Peptide) is a research peptide not approved by the FDA for human use. It is sold only as a research chemical, and StackTrax does not endorse or facilitate personal use.
Quality varies enormously among research-chemical suppliers. At minimum, look for:
StackTrax’s preferred partner NextGen Peptides does not currently carry DSIP (Delta Sleep-Inducing Peptide)in their catalog, which is why you don’t see a direct purchase link here. Other major research-chemical suppliers carry it; we don’t specifically recommend one for this compound.
Build your protocol, log every dose, monitor your body's response, and get reminders so you never miss a dose.
Start Tracking FreeDisclaimer: This guide is for educational and informational purposes only and is not intended as medical advice, diagnosis, or treatment. The compounds discussed are not FDA approved for human use. Always consult a qualified healthcare provider before starting any new supplement or peptide protocol. StackTrax does not sell peptides or supplements directly — purchase links go to third-party vendors. StackTrax is not responsible for the products, quality, or business practices of any third-party vendor. This page contains affiliate links — StackTrax may earn a commission on purchases at no extra cost to you.
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StackTrax guides cover peptides and compounds that are not FDA-approved for the uses discussed. The dosing, reconstitution, and safety information is compiled from published research and community protocols for educational purposes only.
Before using any compound mentioned here, consult a qualified healthcare provider. StackTrax does not sell, prescribe, or recommend these substances for personal use.
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